- Mitsuki Koyama (神山 満月 Kōyama Mitsuki?) Voiced by: myco (Japanese), Katie Rowan (English)
- A 12-year-old girl who dreams of becoming a pop singer, but who has a  tumor in her vocal cords which restricts her ability to sing. She grew  up in an orphanage, and then later went to live with her strict  grandmother, Fuzuki, who forbade her from singing. When Mitsuki learns  that she'll die if her vocal cords aren't removed, she refuses the  surgery, saying she is more afraid of never singing again than she is of  dying. With Takuto's help, she transforms into Fullmoon (フルムーン Furumūn?), a 16-year-old pop idol,  completely free of cancer and able to sing. As Fullmoon, she is  discovered by Seed Records during an audition, and in both the manga and  anime she is depicted as releasing several hit singles. The anime ending theme songs are all supposedly sung by Fullmoon. Mitsuki chooses the stage name Fullmoon because mitsuki means "full moon" in Japanese, and because her childhood friend, Eichi Sakurai, wants to become an astronomer,  and the name reminds her of him. Mitsuki decided to become a singer  when she was ten years old, because she made a promise with Eichi that  they would fulfill their dreams the next time they met.
- Mitsuki desires to become a singer because she wants to tell Eichi that she loves him. However, the shinigami  eventually discover Eichi is dead. In the manga, they realize Mitsuki  knew this all along; in the anime, Mitsuki learns of his death during a  trip to America. Both the manga and anime revolve around Mitsuki dealing  with Eichi's death, as well as her eventual feelings for Takuto.
- Mitsuki is portrayed as an assertive young girl whose personality  has matured far beyond her chronological age, and who, in spite of  terrible circumstances, stays optimistic and determined. She smiles,  even when she harbors pain inside herself. Eichi observes this,  comparing Mitsuki to the moon: "The other side of the moon has craters  made by meteors...the moon shines while hiding all its wounds" (chapter  3). This trait is also noted by Takuto. Although she always smiles, deep  down she is suffering largely due to her desire to see Eichi (as well  as her grief over his death). She blames herself for his death because  he would not have gotten on the plane if she had confessed to him. Her  grief causes her to withdraw from everyone and even considers suicide  just so that "she can go to the world Eichi is at".
- Halfway through the series, Mitsuki realizes that she loves Takuto  but feels guilty for it because she is afraid of forgetting Eichi. With  the help of Meroko, she decides that she loves them both and is able to  confess to Takuto, as well as accept that Eichi would have wanted to her  to be happy. By the end of the series, she is cured of her illness and  is able to pursue a singing career and relationship with Takuto, but  keeps Eichi in a special place in her heart. Mitsuki's corkscrew  hairstyle was inspired by Ai Kago of the group Morning Musume.[2] Mitsuki herself is modeled on one of Arina Tanemura's assistants, Airi Teito.[3]
- Eichi Sakurai (桜井 英知 Sakurai Eichi?) Voiced by: Ryohei Kimura (Japanese), Graden Gant (English)
- Mitsuki's childhood friend and first love. In the anime, he is six  years older than her; in the manga, he is four years older. He is a kind  and gentle boy, and dreams of becoming an astronomer. In the manga,  Eichi used to hate the moon because it saw him cry after his  grandfather's death, but after meeting Mitsuki, he grew to love the  moon. After his parents died, Eichi lived with his grandfather. When he  died as well, Eichi moved to the orphanage where he met Mitsuki. They  became fast friends, and he eventually fell in love with her, confessing  his feelings just before moving to America. Mitsuki was heartbroken  when he left, as she could not yet confess her true feelings to him.  Part of the reason she wanted to become a singer was to find him. In the  manga, Eichi dies when his flight to America crashes (which Mitsuki  learns immediately); in the anime, Eichi dies in a car accident a few  months after moving (which Mitsuki doesn't find out until her trip to  America, two years later). In the manga, Takuto's first assignment was  taking Eichi's soul, but Eichi refused to depart the world and instead  stays near Mitsuki as a spirit, which gives her the power to see shinigami.  He stays with her until the end of the manga, when he leaves after  seeing that she is now happy and wants to live on, and no longer needs  his presence. As he disappears, he tearfully smiles at her.
- Fuzuki Koyama (神山 文月 Kōyama Fuzuki?) Voiced by: Kazuko Sugiyama (Japanese), Maureen Jones (English)
- Mitsuki's maternal grandmother. She took in Mitsuki when she was 10  and barely spoke to her, likely because she saw Mitsuki as the reminder  of the affair that stole her daughter from her. She initially hates  music because she believes that it has stolen everyone she has loved.  She becomes angry when Mitsuki sings in her house. After Mitsuki runs  away from home to become Fullmoon, disappearing from her life, Grandma  Fuzuki constantly worries about her, gradually accepts the fact that she  cannot keep Mitsuki from music, and the two reconcile. In the manga, as  a young woman Fuzuki was best friends with Moe Rikyou (the human who  became Meroko), and they both fell in love with a violinist, Seijuro  Koga. He chose Fuzuki as his fiancée,  but Fuzuki refused the engagement out of loyalty to Moe. When Fuzuki  announced this to Seijuro, she gave him a final kiss, but Moe, already  hearing of their engagement, misread the scene, ran off, and committed  suicide in despair. Fuzuki later married another man and had Hazuki, who  became Mitsuki's mother. Seijuro married another woman, who gave birth  to Aoi Koga--Mitsuki's father. At the end of the manga, Fuzuki reunites  with Seijuro (both are by then widowed), and they attend Mitsuki's  concert together--strongly implying they are finally a pair. In the  anime, Fuzuki was engaged to a man who wanted to become a famous  pianist. He became obsessed with practicing the piano, and when she  suggested he should relax a bit, he said she did not understand and left  Japan, breaking Fuzuki's heart.
- Yoneya "Yone" Tanaka (田中 よね Tanaka Yone?) Voiced by: Mayumi Akado (Japanese), Suzette Mattar (English)
- Fuzuki's maid. She acts silly at times, but cares deeply for both  Fuzuki and Mitsuki. Tanaka is skilled at cooking, cleaning, shopping,  and appears to take pride in her abilities as a maid. She is also  something of a snoop and often eavesdrops on conversations. In the  anime, Tanaka is shown as loving music and she has a radio with  headphones so that she can listen without Fuzuki knowing; Mitsuki  sometimes uses this to blackmail Tanaka. Tanaka also has a crush on  Wakaoji and is jealous of Oshige, mistaking her to be Wakaoji's fiancée.  In one episode, she challenges Oshige to a contest to see which of the  two would make a better bride. Although Tanaka wins all events, she  concedes the contest when she sees Wakaoji and Oshige laughing together,  believing the two are in love (which is actually true in the manga, but  not in the anime).
- Keiichi Wakaoji (若王子 圭一 Wakaōji Keiichi?) Voiced by: Teruaki Ogawa (Japanese), Gerrick Winston (English)
- Mitsuki's doctor. He played keyboard in the band ROUTE:L along with  Mitsuki's father, Aoi Koga, and Takuto Kira, but he quit after Aoi's  death. Fans called him the "Prince of ROUTE:L" because wakaōji  means "young prince" in Japanese. In the manga, Wakaoji performed the  surgery on Takuto to remove the tumor in his vocal cords and witnessed  Takuto's suicide. Mitsuki learns that Wakaoji loved her mother because  of a letter he thought she had written him, but Wakaoji falls in love  with Oshige when he discovers the letter was from her. In a side story,  he asks Oshige to marry him and she accepts. In an episode of the anime,  Mitsuki asks him to go out with her and he says yes. He cares for  Mitsuki because she looks like her mother.
- Masami Oshige (大重 正実 Ōshige Masami?) Voiced by: Tomomi Seo (Japanese), Kris Rundle (English)
- Fullmoon's 28-year-old manager, and a former avid fangirl of ROUTE:L, especially Wakaoji. She started out as an unsuccessful idol singer, under the stage name Yuina Hanakazari (花飾 結菜 Hanakazari Yuina?),  before moving into management. In the manga, she has an affair with her  boss out of loneliness despite his being married. She truly loves  Wakaoji, having been smitten with him since his days in Route:L, but she  feels she is too old and unworthy of true love with a man. To cope with  this despair, as well as with the pressures of her job, she often loses  herself in a bottle of sake.  (In reality, Arina Tanemura says Masami is a heavy drinker because  Tanemura's editors like to drink, and Oshige's name is a hybrid of the  editors' names.) At the end of the manga, Wakaoji discovers Masami is  the one who composed the mysterious love letter, making her the one he  really loved all that time, and so asks her to marry him.
- Madoka Wakamatsu (若松 円 Wakamatsu Madoka?) Voiced by: Kana (Japanese), Carol-Anne Day (English)
- Madoka Wakamatsu is the stage name of Chisato Kurebayashi (暮林 千暁 Kurebayashi Chisato?).  Madoka is Fullmoon's rival in the music industry, who at the same time  befriends 12-year-old Mitsuki. While talented, she is constantly  upstaged by Fullmoon because she initially lacks the heart Mitsuki gives  her songs. In addition, she is insecure because she had plastic surgery  to make herself beautiful as a celebrity and was disowned by her family  as a result. Madoka has a small pig called Gu-chan (ぐっちゃん?),  who worships her. Although she sometimes takes out her anger on  Gu-chan, she is genuinely fond of him. In the manga, Madoka is shown as  having pride as well as ambition: she refuses to cheat to win over  Fullmoon, even once resigning a commercial offer to Fullmoon when she  realizes that Fullmoon would have won if Madoka hadn't inadvertently  stolen her lyrics. In the anime, Madoka is not above using underhanded  tactics to best Fullmoon and does so several times, although she  eventually changes her ways--particularly after learning some humility  the hard way. In both versions, Madoka cares very much about  Mitsuki/Fullmoon by the end of the story. At the end of the anime  (episode 52), Madoka brings Mitsuki flowers following her surgery, and  at the end of the manga, Madoka cries when thinking about Fullmoon  having cancer: "Why? Why does it have to be her?" (chapter 29).
- Aoi Koga (古雅 葵 Koga Aoi?) Voiced by: Hiroki Takahashi
- Mitsuki's dead father, and former guitarist and songwriter for the  band ROUTE:L. He acted as a father figure for the orphaned Takuto. In  the manga, he died in an accident while driving Hazuki to the hospital  to give birth to Mitsuki; in the anime, he died when Mitsuki was one  year old.
- In the manga, Aoi is shown as a laid-back, cool-tempered man. Arina  Tanemura states that "He loves wearing Buddhist priest work clothes!"  Aoi was very close to his bandmates and friends, Keiichi Wakaoji and  Takuto Kira. He asked Takuto to name his daughter, and Takuto decided on  Mitsuki (vol. 4, bonus manga, Totsugeki Dokodoko). He is only briefly seen in the anime, including a scene where he gives a music box to Hazuki when she named their daughter Mitsuki.
- Hazuki Koyama
- Mitsuki's dead mother. Like Mitsuki, she was physically weak and  often fell ill. She is also a spinning image of Mitsuki. She had loved  Aoi for a long time, against the wishes of her strict mother, and  married him after becoming pregnant with Mitsuki. In the anime, she is  scene in flashbacks attending Aoi's concert and receiving the music box  Mitsuki now has from Aoi. She died giving birth to Mitsuki.
- In the anime, she was confident she was carrying a girl and agreed  with Takuto that Mitsuki was a perfect name. She rarely appears in the  manga, only in a couple of flashbacks.
- Nachi (那智 Nachi?)
- The lead singer of the duo OZ, who befriends Mitsuki (as Fullmoon)  because she was the first person in the music industry to genuinely  smile as she spoke to him. He cherishes her friendship and takes it upon  himself to find a stalker hurting people close to her. Nachi and Madoka  fall in love, though Gu-chan is jealous of him. When Madoka finds he  has an old photo of her with her unattractive childhood fiancé, Soichiro  Shido (紫堂 総一郎 Shidō Sōichirō?),  she assumes Nachi is Soichiro's friend, pretending to love her to get  revenge for her rejection of Soichiro. Madoka apologizes to Soichiro's  mother and asks to break off the engagement because she loves Nachi,  only to discover Soichiro is Nachi, after having plastic surgery  to become an idol in hopes of making her love him. In the end, they  remain engaged and a happy couple. Nachi does not appear in the anime.
- Hikari Hayashi (林 光理 Hayashi Hikari?)
- Hikari was Takuto's girlfriend while he was alive. Takuto discovered  that she was cheating on him and the two were on the verge of breaking  up when Takuto attempted suicide and went into a coma, after which  Hikari realized that she still loved him. She later sees Takuto (visible  to humans while he was about to go on a date with Mitsuki) and attempts  to revive their relationship, which causes problems between Takuto and  Mitsuki. Hikari only appears in the manga.
[edit] Shinigami
The 
shinigami are the spirits of humans that committed 
suicide, who are then punished with the task of collecting souls. If a 
shinigami fully remembers his or her past life before becoming a full 
shinigami,  he or she disappears and becomes a ghost. In the manga, Mitsuki is the  only human who knows about the shinigami (other than Grandma Fuzuki, who  befriends Meroko in her "plushie doll" form, but does not know she's a  shinigami, nor realizes Meroko is a friend from many years ago).  However, in the anime, when Mitsuki admits to Oshige and Wakaoji her  double-identity, she also admits the existence of Takuto and Meroko, as  well as their supernatural powers. Oshige and Wakaoji befriend Takuto  and Meroko, and frequently interact with them when they're in doll form.
- Takuto Kira (タクト·キラ Takuto Kira?) Voiced by: Yakkun Sakurazuka (Japanese), Jeffrey Watson (English)
- Takuto is Meroko's partner and trainee, and they are assigned to take Mitsuki's soul. His shinigami costume is a cat outfit plus a backpack with wings, without which, as a trainee shinigami, he cannot fly. Takuto is capable of transforming into a anthropomorphic cat plushie.  Moved by Mitsuki's plight, he transforms her into the 16-year-old  Fullmoon. Takuto falls in love with Mitsuki as the story goes on, and  despite the 12 year age difference between them, they become a couple at  the end. As the series progresses, he remembers his past as Takuto Kira  (吉良托人 Kira Takuto?),  the lead singer of ROUTE:L, the band that both Mitsuki's father and her  doctor were in. After a malignant tumor in his throat took his voice,  he attempted suicide by jumping from the top floor of the hospital,  witnessed by Dr. Wakaoji. He remained in a coma for the next two years.  In the manga, a twelve year-old Takuto named Mitsuki before she was  born, and later met her at the orphanage when she was four years old and  promised to protect her. At the end of the series, Takuto saves  Mitsuki's life, violating fate and his duty as a shinigami.
- At the end of the manga, he is seen as a human again in the  hospital, having lost three months of memories. Three years later, he  reunites with Mitsuki during her concert. Mitsuki jumps off stage  mid-song and confesses her feelings to him. They kiss amid cheers from  the concert crowd. In the anime, the circumstances of Takuto's death are  changed: he is in a motorbike accident and dies rather than remaining  in a coma. After being given a second chance at life, Takuto has no  memory of his former lives as human or shinigami, but still carries the  cat charm Mitsuki gave him. In the final scene, Meroko (now an angel)  leads Mitsuki to Takuto. Mitsuki calls out to him, and he recognizes  her.
- Meroko Yui (めろこ·ユイ Meroko Yui?) Voiced by: Chieko Honda (Japanese), Leda Davies (English)
- Meroko is a rabbit shinigami with long ears, capable of transforming into an anthropomorphic bunny stuffed toy.  Her shinigami costume in the manga is black; whereas, in the anime it  is red. Meroko is particularly insecure in relationships. At one point  she laments, "I've finally run away from love... but when I fell in love  and lost it, I realized that there's no place to run anywhere, anymore.  Do I have to repeat this forever? Is this my punishment?" (bonus story  in manga volume 3, A Kiss for Meroko). This insecurity gives her  jealousy towards Mitsuki. Meroko is Takuto's partner and has an  unrequited infatuation with him. Her jealousy in the manga causes her to  act out almost violently against Mitsuki. In the anime, she is more  passive; however, the anime depicts her love for Takuto as being much  deeper and more permanent than the manga. Meroko is Izumi's former  partner; in the manga, it is Izumi who selects her unique costume. Both  the manga and the anime reveal a previous relationship between Izumi and  Meroko and allude to it as being unhealthy but mutual. Eventually Izumi  ends the relationship and partnership; Meroko is forced to train Takuto  as a replacement. The anime does not address Meroko's past, while the  manga does: As a human, Meroko was named Moe Rikyo (里匡萌 Rikyō Moe?),  and was the best friend of Mitsuki's grandmother, Fuzuki. Fuzuki was in  an arranged engagement to another man, but both she and Moe fell in  love with Seijuro Koga, a handsome violinist. However, Seijuro returned  only Fuzuki's affections and arranged things so the two could be  engaged. Fuzuki's loutish ex-fiancé was passed on to Moe, who, shocked  by the new arrangements, sought out Fuzuki to verify the truth. At the  same time, Fuzuki broke off her relationship with Seijuro and was giving  him a final kiss when Moe arrived. The upset Moe ran away; soon  afterwards, her new fiancé attempted to rape her. Feeling betrayed by  her friend, Moe committed suicide. In the manga, Meroko learns Seijuro  is Mitsuki's grandfather and assumes Mitsuki is the descendant of  Fuzuki's betrayal. In a rage, Meroko tries to take Mitsuki's soul with a  whip, but Takuto intervenes. It is later revealed that Fuzuki did not  marry Seijuro but later married another man, with whom she raised Hazuki  Kouyama, Mitsuki's mother; Seijuro married another woman, and their  child was Aoi Kago, Mitsuki's father.
- Meroko eventually makes amends in the manga both by befriending  Fuzuki in her rabbit form and by appearing silently as Moe, allowing  Fuzuki a chance to explain and apologize although shinigami law prevents  her from replying.
- The manga ends with Meroko and Izumi reconciling their relationship  as well as becoming shinigami partners once more. In the anime, Meroko  is exiled from the shinigami and resolves to become a ghost in order to  save Takuto; in reward for this kindness, she is made into an angel and  given Takuto's soul to deliver a second chance.
- Izumi Rio (いずみ·リオ Izumi Rio?) Voiced by: Megumi Ogata
- Izumi is a cold and distant shinigami assigned to the Pediatrics Ward. He can transform into an anthropomorphic dog plushie,  but rarely does so because it takes a lot of energy and he says it is  embarrassing. He likes to call other characters by nicknames.
- In the anime, Izumi's background is not mentioned and he is  portrayed as a cold-hearted antagonist. He makes several attempts to  steal Mitsuki's soul, and although he claims to love Meroko, he  frequently does things to hurt her. He also implies that he was  responsible for Takuto and Meroko being assigned to Mitsuki in the hopes  it would cause Takuto to remember his past life as a human and turn him  into a ghost. The anime portrays Izumi's sole motivation as the need to  regain Meroko and cause Takuto pain in the process.
- The manga illustrates Izumi as mischievous but not sadistic, and  over the course of the series, he also befriends Mitsuki and the others.  Izumi's background in the manga is elaborate: In his human life, he was  a boy named Lio Izumi (泉利緒 Izumi Rio?)  whose mother was abusive; it is implied that the young Izumi looked  much like his late father, thus invoking his mother's rage. In a  desperate attempt to see his mother smile again, six-year old Izumi ran  onto the train tracks - but though he saw his mother smile as he was  hit, Izumi woke up again as a shinigami, dissatisfied. In the manga, it  is stated that Izumi retained all of his memories after death, a very  unusual feat for a new shinigami. Eventually, Mitsuki helps him realize  that he had wanted his mother to call him back from the tracks. At the  end of the manga, Izumi and Meroko team up once again and become  sweethearts.
- Jonathan (ジョナサン Jonasan?) Voiced by: Norihisa Mori
- Jonathan is the shinigami who becomes Izumi's partner after Meroko leaves. He wears a top hat  and often speaks rather odd phrases in English. Throughout the series,  he appears subservient to Izumi, while conducting covert operations  including revealing to Mitsuki that the shinigami already knew  that Eichi was dead and becoming a fanatic who tries to harm Fullmoon  and her friends. In the manga, it is eventually revealed that he is  really Sheldan (シェルダン部長 Sherudan-buchō?),  the head of the pediatrics ward. He attempts to take Mitsuki's life,  but is stopped by Takuto, Meroko, and Izumi. He was the second shinigami  to be born, and shows great affection towards Mystere. In the final  chapter, he uses up all his powers to heal Takuto's throat and give him  his voice back, and disappears along with Mystere. In the anime  adaptation, Jonathan's role is minor, acting only as Izumi's sidekick  and a source of annoyance.
- In an author's freetalk in the manga, Tanemura mentions that one day at work, she drew a picture of what she thought Peeves from Harry Potter  looked like. She showed it to her assistants, who laughed and said it  did not look anything like Peeves. Tanemura decided not to waste it, and  used the sketch as the design of Jonathan in ghost form.[4]
- Death Master (死神主人 Desu Masutā?)
- Also called Mystere (ミスティア Misutia?), the Death Master was the first human soul to descend to the Underworld  and is the crowned queen of the Underworld. After discovering she could  take the souls of humans, she encountered a dying young girl who asked  her if she was a shinigami, which convinced her that she was one. Fragile and sentimental, she is believed to be the most powerful shinigami.  When Meroko enters her room to erase Mitsuki's name from the rolls of  the dead, Mystere gives her the keys to free Takuto, and later she  listens with a smile to Mitsuki's final performance as Fullmoon. At the  end of the manga, when Mystere and Sheldan disappear after using up  their power healing Takuto's throat, they seem to show great affection  for each other, and Mystere says that unlike the last time she died, she  has no regrets about it. In the anime, there is no backstory to her,  and she appears briefly near the end, forgiving Takuto and Meroko,  forbearing Mitsuki's and Takuto's deaths, and granting Meroko the status  of an angel.

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